GCSE – Biology

GCSE Biology

Overview of AQA GCSE Biology qualifications

Subject content:

1. Cell biology

Cells are the basic unit of life. Gene-controlled structures allow specialized functions. Mitosis enables growth by creating identical cells. Stem cell technology repairs organs by growing new tissue from versatile early-stage cells.

Scope of studyContent
Cell structure• Eukaryotes and prokaryotes
• Animal and plant cells
• Cell specialisation
• Cell differentiation
• Microscopy
• Culturing microorganisms
Cell division• Chromosomes
• Mitosis and the cell cycle
• Stem cells
Transport in cells• Diffusion
• Osmosis
• Active transport

2. Organisation

This section covers how the digestive, respiratory, and circulatory systems support the body, with a focus on reducing risks through diet and lifestyle. It also explores how plants rely on environmental conditions for photosynthesis.

Scope of studyContent
Principles of organisation• Cells as building blocks of all living organisms.
• Tissue as a group of cells
• Organs
• Organ systems
Animal tissues, organs and organ systems• The human digestive system
• The heart and blood vessels
• Blood
• Coronary heart disease: a non-communicable disease
• Health issues
• The effect of lifestyle on some non-communicable diseases
• Cancer
Plant tissues, organs and systems• Plant tissues
• Plant organ system

3. Infection and response

Pathogens cause diseases by using hosts to grow and produce toxins. The body fights them with barriers, immune responses, and vaccines. Antibiotics work against bacteria, but resistance is increasing, requiring new treatments.

Scope of studyContent
Communicable diseases• Communicable (infectious) diseases
• Viral diseases
• Bacterial diseases
• Fungal diseases
• Protist diseases
• Human defence systems
• Vaccination
• Antibiotics and painkillers
• Discovery and development of drugs
Monoclonal antibodies• Producing monoclonal antibodies
• Uses of monoclonal antibodies
Plant disease• Detection and identification of plant diseases
• Plant defence responses

4. Bioenergetics

Plants harness solar energy in photosynthesis, producing oxygen. Both plants and animals use oxygen for aerobic respiration to release energy. Anaerobic respiration occurs without oxygen, especially during intense exercise, leading to energy production but also lactic acid buildup and fatigue.

Scope of studyContent
Photosynthesis• Photosynthetic reaction
• Rate of photosynthesis
• Uses of glucose from photosynthesis
Respiration• Aerobic and anaerobic respiration
• Response to exercise
• Metabolism

5. Homeostasis and response

The body maintains stable conditions through control systems involving the nervous and hormonal systems. Fast responses come from the nervous system, while hormones regulate slower changes, especially in reproduction.

Scope of studyContent
Homeostasis• Control Systems:
– Receptors
– Coordination centers
– Effectors
The human nervous system• Structure and function
• The brain
• The eye
• Control of body temperature
Hormonal coordination in humans• Human endocrine system
• Control of blood glucose concentration
• Maintaining water and nitrogen balance in the body
• Hormones in human reproduction
• Contraception
• The use of hormones to treat infertility
• The role of thyroxine and adrenaline in the body
Plant hormones• Control and coordination
• Use of plant hormones

6. Inheritance, variation and evolution

Meiosis creates unique offspring by combining genes from both parents. Mutations can be harmful or beneficial, driving natural selection and evolution.
Selective breeding and cloning enhance desirable traits, while genetic engineering transfers genes between species, though it’s controversial.

Scope of studyContent
Reproduction• Sexual and asexual reproduction
• Meiosis
• Advantages and disadvantages of sexual and asexual reproduction
• DNA and the genome
• DNA structure
• Genetic inheritance
• Inherited disorders
• Sex determination
Variation and evolution• Variation
• Evolution
• Selective breeding
• Genetic engineering
• Cloning
The development of understanding
of genetics and evolution
• Theory of evolution
• Speciation
• The understanding of genetics
• Evidence for evolution
• Fossils
• Extinction
• Resistant bacteria
Classification of living organisms• Carl Linnaeus’ classification system
• Carl Woese’s three-domain system
• Evolutionary trees

7. Ecology

Ecosystems recycle energy and materials like carbon and water, supporting interconnected species. Human survival depends on these systems, but our actions threaten biodiversity. Sustainable practices are essential to protect our future.

Scope of studyContent
Adaptations, interdependence and competition• Communities
• Abiotic factors
• Biotic factors
• Adaptations
Organisation of an ecosystem• Levels of organisation
• How materials are cycled
• Decomposition
• Impact of environmental change
Biodiversity and the effect of human interaction on ecosystems• Biodiversity
• Waste management
• Land use
• Deforestation
• Global warming
• Maintaining biodiversity
Trophic levels in an ecosystem• Trophic levels
• Pyramids of biomass
• Transfer of biomass
Food production• Factors affecting food security
• Farming techniques
• Sustainable fisheries
• Role of biotechnology

8. Key ideas

Biology revolves around a few key concepts:

– Life processes rely on molecules with structures related to their functions.
– Cells are fundamental units, forming tissues, organs, and systems.
– Organisms interact in ecosystems, adapting to environments.
– Photosynthesis is crucial for life on Earth, producing organic compounds and oxygen.
– Cellular respiration fuels life processes.
– Chemicals cycle through ecosystems.
– An organism’s traits are shaped by its genome and environment.
– Evolution via natural selection explains biodiversity and relationships among species.

Required practical activities

1. Observe and draw plant and animal cells using a light microscope.

2. Test the effect of antiseptics or antibiotics on bacterial growth with agar plates.

3. Explore how salt or sugar concentrations affect plant tissue mass.

4. Test for carbohydrates, lipids, and proteins using Benedict’s, iodine, and Biuret reagents.

5. Examine how pH influences amylase enzyme activity by tracking starch digestion over time.

6. Investigate how light intensity impacts photosynthesis using pondweed.

7. Conduct an experiment on a factor affecting human reaction time.

8. Study how light or gravity affects seedling growth, recording length and drawing results.

9. Measure population size in a habitat and analyze the effect of a factor on species distribution.

10. Assess temperature’s impact on milk decay by tracking pH changes.

For detailed information about the General Certificate of Secondary Education (GCSE) and how it can shape your academic future, click here to explore: GCSE Information

Assessment

Type of assessmentContentFinal scoreWeighting of
final grade
Paper 1: Multiple choice, structured, closed short answer and open response.Topics 1–4: Cell biology; Organisation; Infection and response; and Bioenergetics.100 marks50%
Paper 2: Multiple choice, structured, closed short answer and open response.Topics 5–7: Homeostasis and response; Inheritance, variation and evolution; and Ecology.100 marks50%
Works are assessed at the Foundation and Higher Tiers

Assessment objective weightings for GCSE Biology

Assessment Objectives:

AO1: Demonstrate knowledge and understanding of scientific ideas, techniques, and procedures.
AO2: Apply knowledge of scientific ideas and enquiry, as well as techniques and procedures.
AO3: Analyze information to interpret, evaluate, make judgments, draw conclusions, and improve experimental procedures.

Assessment objectives (AOs)*Component
weightings
Paper 1
(%)
Component
weightings
Paper 2
(%)
Overall weighting
(approx %)
AO137‒4337‒4340
AO237‒4337‒4340
AO317‒2317‒2320
Overall weighting of components5050100
*Assessment Objectives (AOs) are set by Ofqual and are common to all GCSE Biology specifications and exam boards.

Assessment weightings

The marks on the papers will be scaled according to the weighting of each component. Students’ final marks will be the sum of these scaled marks. Grade boundaries will be determined based on this total scaled mark. The scaling and total scaled marks are detailed in the table below.

ComponentMaximum raw markScaling factorMaximum scaled mark
Paper 1100x1100
Paper 2100x1100
Total scaled mark:200

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